American Academy of Professional Coders (AAPC) 2025 – 400 Free Practice Questions to Pass the Exam

Keratohyaline granules play a crucial role in the skin by facilitating hydration and enhancing impermeability. They are found primarily in the stratum granulosum, a layer of the epidermis. The granules contain a mixture of proteins, including filaggrin, which aids in the aggregation of keratin filaments, thus promoting the formation of a protective barrier. This barrier is essential for retaining moisture within the skin, preventing dehydration, and ensuring that the skin remains hydrated.

Additionally, the keratohyaline granules contribute to the overall barrier function of the skin by helping to create a waterproof layer that protects underlying tissues from external environmental factors, pathogens, and toxins. This impermeability is fundamental for maintaining skin integrity and overall health. By establishing a robust barrier and retaining hydration, keratohyaline granules play an integral part in the skin's physiology, making option B the correct choice.